01Nitrates
LEVITRA stays closed with nitrates, regular or intermittent, and with nitric oxide donors. PDE5 inhibitors may potentiate the hypotensive effects of nitrates. In healthy subjects, LEVITRA 20 mg dosed 24 hours before 0.4 mg nitroglycerin did not show additional blood-pressure effects. A suitable time interval for patients who need a nitrate has not been determined.